Your plan in general looks fine. In lieu of two 2-loop and one 4-loop separate manifolds and three zone valves, you might want to consider a single eight loop manifold and eight loop actuators.
Upfront cost and efficiency will largely be determined by the type of HR emitter you construct and the heat source you select. A concrete slab emitter often is both the lowest cost and highest efficiency. A below-floor plate HR emitter is the often the highest cost and lowest efficiency. An above-floor HR emitter is somewhere in between these. A heat pump based heat source is the highest efficiency (really the highest coefficient of performance and the lowest operational cost), but also has the highest acquisition cost. An electric boiler is 100% efficient (but only has about one third the coefficient of performance of a heat pump based heat source) and often has the lowest acquisition cost while also being very robust (i.e., long life and low maintenance cost). Electric boilers are also easy to DIY install and setup. Some electric boilers like the NextGen boiler are also HR plug and play and can save a lot of HR component expense and hassle:
NextGen Boiler
A condensing gas boiler is similar to an electric boiler, but is not as robust and I don’t know of any available in the states that are HR plug and play. As your home becomes more energy efficient (i.e., better insulated and sealed), heat source efficiency (or coefficient of performance) becomes less important because your operational cost becomes quite small in any event. So a ROI analysis is really needed to make the best economic selection.
John Siegenthaler’s “Modern Hydronic Heating” is a great source of everything you need to know about this subject.