A little confused by your question so I apologize if Im giving you info you already know
Most systems ask for around 400cfm per ton , little less in heating . Most ecm fans can handle a wide range of parameters
For required cfm per room with enough heat , you first size the floor room by room ( equip size )
then you go room by room get the load per room ( required buth )
the formula for btuh is multiply you temp split ( about 30 ) by 1.08 and then by your cfm
so if you know your load call that L it would look like ------L=30times1.08 times Y ( now your cfm )
multiply 30 and 1.08 and divide that from L this should give you your cfm for that room if Im not mistaken
Once you know your required cfm to deleiver the heat required selecting duct size ,location , and returns should all be standard
Just remember to confirm you static pressure to each room after as Im sure you know
This is well outside my scope of work , and is strictly from memory so please feel free to correct me