The most important question is where is your new home going to be located?
If you insulate the floor of the crawl space with foam and have duct openings in that space to condition it, what do you plan to use to cover the foam to address potential fire issues? In general, you shouldn't leave ignitable foam exposed in conditioned spaces.
That spray foam is expensive (>$1/inch per square foot). Another option would be to fill the crawl space with sand or gravel with just enough material to get it level, then lay down a plastic vapor barrier with taped seams, then lay down sheets of rigid insulation, either XPS or less expensive EPS (you might look into finding reclaimed insulation to save even more), 2" to 4" thick. Then pour a 2" thick concrete slab over the insulation. This is often referred to as a "rat slab". Then you could use your entire crawl space as either a supply or return plenum and possibly forgo some duct work costs.
Is radon a concern in your area? If so, you should place perforated plastic pipe in the sand/gravel fill and provide an exit duct to get any potential gasses out of the area.
Here is a link that discusses sealed conditioned crawl spaces and the issues of using that area as a plenum:
http://www.buildingscience.com/docu...-and-codes