XPS is blown with a mix of environmentally damaging HFCs (the predominant of which is HFC134a, which has a global warming potential 1400x CO2, among it's less desirable properties) whereas EPS and polyiso are blown with a low-impact HC (pentane at about 7X CO2). Worse, as the HFCs leak out over 4-5 decades the material loses performance, eventually hitting the same R value as EPS blown at the same density and thickness. At 4" exterior foam in a zone 4 climate you'll get better lifecycle performance out of 2" of EPS on the exterior, with 2" of polyiso between the EPS and structural sheathing, despite nominally the same day-1 R-value as 4" of XPS. In most markets EPS and polyiso are cheaper per unit R too. (About 10 cents per R per square foot compared to XPS at about 13 cents/R-foot.)
Cellulose in the cavities is cheap performance, and the borate fire retardents are anti-termite. The difference in whole-wall R (after thermal bridging of the framing is factored in) between R23 Roxul and a cellulose solution is less than 1, a difference that can be made up with another 1/4" of EPS.
The whole-wall R of either the 2x6 16" o.c. Roxul + 4" XPS or 2x6 16" o.c. cellulose +2" polyiso + 2" EPS is about R35 after thermal bridging, which is on the fat side of being fully economic for a zone 4 climate. As a starting point, take a look at
Table 2, p10 of this document, which recommends R25 for a whole as the point where you need to sharpen your cost-accounting pencil. A pretty-good R25 wall would be backing off to 2x4 16" o.c. framing and 4" of EPS-only (or 3" of polyiso only, or 2" of exterior iso + 1" of exterior EPS.) You could also get there with 2x6 16" o.c./cellulose and 2" of exterior foam (or 2"
Roxul Comfortboard IS but that's usually more expensive.)
None of these stackups would require an interior side vapor barrier in a marine zone 4 climate, or any interior layers more vapor retardent than standard latex paint (about 3-5 perms), and would be made
less resilient to moisture by inserting an interior side vapor barrier. An inch of exterior foam or rigid rock wool would be enough, even if you WEREN'T giving the siding furred out ventilation gap/rainscreen.
Building the foundation walls with insulated concrete forms (ICF) with the exterior foam of the ICF co-planar or a half-inch shy of your wall foam would make it easier to get a continuous thermal envelope for all 6 sides of the cube (including your sub-slab foam- 2" EPS recommended there). With an exterior-side only approach to basement insulation you would have to insulate under the footing too, not just the slab. With an interior side only approach you'd be fine with 1" EPS that extends down to the footing, thermally breaking the slab edge from the foundation wall, and building out a non-structural 2x4 studwall with R15 Roxul (safer below grade than cellulose, since it can't wick water in the event of flooding), then insulating the band joist and foundation sill with an inch of closed cell spray foam sealing it to the basement wall foam and stud plate, plus R23 Roxul to fatten out the R to reduce the thermal bridge between the foundation sill and exposed exterior concrete.