Efficient Windows is a good starting place for information, specifically on glazing sustems. You also need to go to http://www.energystar.gov. It is a governement site that has listed tested and certified windows that meet the specific requirements of your location. You need window that meet the minimums for your Energy Start zone. That said, there are several factors to pay attention to:
SHGC the lower the better for cooling loads. If you make it too low for your location, you will force the heating systeme to work harder and spend more energy to heat the home. Also, you must pay close attention to the visible light or Vt factor. To get to lower SHHGC, some manufacturers darken the glass. That will mean you will have to probably add interior lighting during the day in darker rooms and that can offset the energy savings. I would sy that best solution for you would be something that gives you less than .40 SHGC and Vt of more that 60% such as Guardian RLE glass. Excellant properties for energy conservation and Vt.
Gas fill can enhance the U-value fo the IG, but there is still a lot of controversy over how long the gass will remain in the cavity. If you select a IG with a U-value of .35, that will probably be an optimum for North Carolinas and you can achieve this without gas.
If you live anywhere near the coast, I would seriously consider impact rate glass, or at a minimum of laminated glass with a .060 PVB innerlayer. This would not be impact "rated" but would offere some added protection against breakage. It also makes you window more secure against break-in and will make the window quieter.
For more information, read this:
Best Vinyl Windows