You have things like bath tubs filled with water, toilet attachments thru nailbase, its a bad idea in my opinion. I can't see a ceramic installation over nailbase ever being successful. In fact I hate OSB installs anywhere near a bathroom. I have had to replace ceramic that blew off the floor after a leak went undected. It was a SIP floor/fibercement/ceramic.... never knew OSB would swell to 1-1/4"