Alan;
Not entirely true, although I will say that because all commercial buildings are designed for occupancy load and required to introduce fresh make up air into the building. The HVAC system becomes less efficient as it is always battling the exterior air, either hot or cold.
Air or heat exchangers can aid in the equipment efficiency by pre-conditioning before entry to the inside.
These air exchangers are also available for residential use but are not mandatory.
2" or 12" does still matter as a matter of energy savings, but will not make much difference for the ability to downsize equipment like you can do in residential buildings.
You will notice that many air conditioned commercial buildings will feel cool and clammy - this is due to the oversized equipment cooling too quick and not dehumidifying, this also leads to sick building syndrome if not properly supplied with fresh air