What fuel source options do you have (e.g., electric, natural gas, etc) and how much do they cost? How well insulated and sealed is this space? Do you need AC too?
Electric space heaters and such are 100% efficient in terms of converting electric into BTUs of heat, but have a Coefficient of Performance (COP) of only 1.0. A mini split has a COP of about 3.0 and will therefore use only one third the electricty as electric space heating. However, for such a small space and likely very small BTU load, I doubt the ROI would be positive if you could find a small enough system.
If you go with an electric space heater, I would think having a thermostat would go a long way to reduce operational cost and improve comfort. This link might be helpful:
Tiny House Energy Efficient Space Heaters